Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetylpyrazine → (E)-1-[2-(bis-Boc-Amino)-4-methylthiazol-5-yl]-3-(dimethylamino)prop-2-en-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetylpyrazine | HCID 30914 | — |
| 반응물 | (E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one | HCID 5825354 | — |
| 반응물 | 2-(Bis-boc-amino-)-5-acetyl-4-methylthiazole | HCID 58930550 | — |
| 생성물 | (E)-1-[2-(bis-Boc-Amino)-4-methylthiazol-5-yl]-3-(dimethylamino)prop-2-en-1-one | HCID 58930666 | 16% |
반응 단계
Following the procedure described for the synthesis of enamino ketone 23a (scheme 6) but substituting 1-(pyrazin-2-yl)-ethanone for the ketone 336, title compound was obtained in 16% yield. 1H NMR (DMSO-d6) δ (ppm): 7.65 (d, J=12.1 Hz, 1H), 5.34 (d, J=12.1 Hz, 1H), 3.14 (s, 3H), 2.87 (s, 3H), 2.50 (s, 3H), 1.51 (s, 18H). MS (m/z): 411.52 (calc) 412.3 (MH+) (found).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08088805B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-c956263b7c384a57a63663a6c4026410 |
| 출처 메모 | uspto-grants-2012_01 |