Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Sulfamoylbenzoic acid → 3-{3-[7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-[1,2,4]oxadiazol-5-yl}-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Sulfamoylbenzoic acid | HCID 229352 | — |
| 반응물 | HCID 178513391 | HCID 178513391 | — |
| 생성물 | 3-{3-[7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-[1,2,4]oxadiazol-5-yl}-benzenesulfonamide | HCID 16068878 | — |
반응 단계
The title compound was prepared from N-hydroxy-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxamidine (example B.1) (195 mg, 0.5 mmol) and commercially available 3-sulfamoyl-benzoic acid (101 mg, 0.5 mmol) according to general procedure II. Obtained after purification by flash chromatography (ethyl acetate/heptane) and crystallization (dichloromethane) as a yellow solid (144 mg, 52%). MS (ISN) 553.3 [(M−H)−]; mp 285° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08093263B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-04e19f8ec2814bf989c7dde574feb2bf |
| 출처 메모 | uspto-grants-2012_01 |