참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4,7-Dichloroquinoline | HCID 6866 | — |
| 반응물 | 2-Methyl-5-nitro-1H-indole | HCID 280313 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | HCID 131729352 | HCID 131729352 | 95.6% |
반응 단계
A mixture of 2-methyl-5-nitroindole (1.34 g) and 4,7-dichloroquinoline (1.53 g) in NMP (1 ml) and 4M HCl in dioxane (0.1 ml) was heated at 145° C. for 2 hours and at 160° C. for 4 hours. After cooling the mixture triturated with ether and the solid collected to give the sub-title compound (2.72 g) as a green solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08093278B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_01 |
|---|
| ORD ID | ord-8782189cd65e4c2b9bd14634dca9706f |
|---|
| 출처 메모 | uspto-grants-2012_01 |
|---|
