Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Acetic acid--tert-butyl 4-carbamimidoylpiperidine-1-carboxylate (1/1)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | HCID 178451986 | HCID 178451986 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 생성물 | Acetic acid--tert-butyl 4-carbamimidoylpiperidine-1-carboxylate (1/1) | HCID 66650050 | 126.2% |
반응 단계
Add 10% Pd/C (0.079 g; 37.12 μmoles) to 4-(N-Hydroxycarbamimidoyl)-piperidine-1-carboxylic acid tert-butyl ester (805 mg; 1.00 equiv; 3.31 mmoles) in acetic acid (15 mL; 261.77 mmoles) and acetic acid anhydride (0.5 mL; 5.29 mmoles). Hydrogenate at room temperature for 7 hr at 20 PSI. Purge flask with nitrogen to provide 1.2 g of a foam. Triturate with acetonitrile and filter to provide 270 mg (28%) of the product as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08093383B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-1b158131581348e781b2317d8767b659 |
| 출처 메모 | uspto-grants-2012_01 |