Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 4-Methyl-2-(methylsulfanyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-Mercapto-4-methylpyrimidine hydrochloride | HCID 178428687 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Methyl-2-(methylsulfanyl)pyrimidine | HCID 821261 | 86.4% |
반응 단계
To a solution of NaOH (7.46 g, 186.4 mmol) in water (120 mL), 4-methylpyrimidine-2-thiol hydrochloride (13.78 g, 84.7 mmol) was added and subsequently iodomethane (13.23 g, 93.2 mmol) was added dropwise under argon atmosphere. It was stirred at room temperature for 2 h. It was extracted with CH2Cl2 (×2). The organic phase was dried over Na2SO4 and concentrated to dryness. The crude product obtained was purified by chromatography on silica gel using hexane-EtOAc mixtures of increasing polarity as eluent, to afford 10.26 g of the desired compound (yield: 86%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536194B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-28d9962299d84e278f896f2ad27afb03 |
| 출처 메모 | uspto-grants-2013_09 |