Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-2-furansulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 4-Methoxy-6-methylpyrimidin-2-amine | HCID 587236 | — |
| 반응물 | 2-Furansulfonyl isocyanate | HCID 23342478 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-2-furansulfonamide | HCID 20390812 | — |
반응 단계
To a solution of 2.10 g of 2-furansulfonyl isocyanate in 40 ml of methylene chloride was added 1.60 g 2-amino-4-methoxy-6-methylpyrimidine. The resulting mixture was stirred for 1 hour at room temperature, then refluxed for 15 minutes, and the solvent was removed under vacuum. The solid obtained was allowed to stand under ethyl ether containing a trace of acetonitrile for one day, and was then filtered and dried to give the desired product melting at 185°-188° (dec).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04169719 |
| 출처 데이터셋 | uspto-grants-1979_10 |
| ORD ID | ord-e008343bb5c146f7a23cf3c4aa20f90c |
| 출처 메모 | uspto-grants-1979_10 |