참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanesulfonic Acid | HCID 6395 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2,3-Dimethylanisole | HCID 76269 | — |
| 반응물 | 3-(3-Benzyl-3h-imidazol-4-yl)-acrylic acid | HCID 53740863 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one | HCID 18405265 | — |
반응 단계
A mixture of 2,3-dimethylanisole (2.0 g), 3-(3-benzyl-3H-imidazol-4-yl)-acrylic acid (3.4 g) and methanesulfonic acid (60 ml) is heated at 90-95° C. for 45 minutes. The cooled reaction mixture is poured into water and is made alkaline with sodium hydroxide solution. The product is extracted into ethyl acetate which is washed with water, dried with sodium sulfate and evaporated in reduced pressure. The crude product is purified by flash chromatography by eluting with methylene chloride-methanol solution. The yield is 1.1 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06313311B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_11 |
|---|
| ORD ID | ord-089ae1521d8c4576ad26f389f08503fb |
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| 출처 메모 | uspto-grants-2001_11 |
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