Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Aniline → 2-chloro-N-phenylquinazolin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2,4-Dichloroquinazoline | HCID 252886 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-chloro-N-phenylquinazolin-4-amine | HCID 317908 | — |
반응 단계
A solution of 2,4-dichloro-quinazoline (15 g), N,N-diisopropyl-ethylamine (24.9 ml) and aniline (7.5 ml) in isopropanol (75 ml) is heated to reflux for 45 min. The cold reaction mixture is filtered and the filtrate is concentrated in vacuo. The residue is crystallized from diethylether-toluene (1:1) to give 2-chloro-4-phenylamino-quinazoline, m.p. 194-196° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06316203B1 |
| 출처 데이터셋 | uspto-grants-2001_11 |
| ORD ID | ord-ce3ea6161b1e453eb066c585f6a0c5fe |
| 출처 메모 | uspto-grants-2001_11 |