Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 429026생성일: 2026년 10월 24일
2-chloro-N-phenylquinazolin-4-amine → N-methyl-[4-(4-phenylamino-quinazolin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride
https://huagongshe.com/ko/reaction/429026
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-chloro-N-phenylquinazolin-4-amine | HCID 317908 | — |
| 반응물 | 4-Amino-N-methylbenzenemethanesulfonamide | HCID 2778131 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Isoamyl Alcohol | HCID 31260 | — |
| 생성물 | N-methyl-[4-(4-phenylamino-quinazolin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride | HCID 9825278 | — |
반응 단계
A solution of 2-chloro-4-phenylamino-quinazoline (0.92 g) (prepared as described in Example 1a and N-methyl-(4-aminophenyl)-methanesulfonamide (0.80 g) in 10 ml of isopentylalcohol is stirred under nitrogen at 170° C. for 15 min in a sealed vessel. The warm reaction mixture is diluted with 10 ml ethanol and the hydrochloride salt, which is crystallizing on cooling, is filtered off to yield N-methyl-[4-(4-phenylamino-quinazolin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride as light yellow crystals melting at 259-263° C.; Rf (A2) 0.11, FAB-MS: (M+H)+=420. Analytical data: C22H21N5O2S+HCl.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06316203B1 |
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| 출처 데이터셋 | uspto-grants-2001_11 |
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| ORD ID | ord-500a0498b86745cab095443c4c237f6d |
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| 출처 메모 | uspto-grants-2001_11 |
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