Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 4-Hydroxy-4-phenylbutanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | gamma-Phenyl-gamma-butyrolactone | HCID 13884 | — |
| 생성물 | 4-Hydroxy-4-phenylbutanamide | HCID 11423922 | 75% |
반응 단계
A mixture of γ-phenyl-γ-butyrolactone (10.30 g, 63.5 mmol) and an excess of ammonia was stirred under nitrogen and a dry ice trap for 8 hours. The dry ice trap was removed and after evaporation of the ammonia 11.27 g of a tan solid remained. Recrystallization of the solid from ethyl acetate-hexane gave 4-hydroxy4-phenyl-butyramide (8.56 g, 75%) as a white solid, mp 85-87° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06316467B1 |
| 출처 데이터셋 | uspto-grants-2001_11 |
| ORD ID | ord-a4ea1a492f1f4bbc9729dcf30c88c50c |
| 출처 메모 | uspto-grants-2001_11 |