Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 430472생성일: 2026년 10월 24일
Hydrochloric Acid → 5-[2-Hydroxy-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-methyl-pentylamino]-phthalide
https://huagongshe.com/ko/reaction/430472
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 5-Acetamido-phthalide | HCID 590968 | — |
| 반응물 | 4-Toluenesulfonic acid-[2-hydroxy-4-(5-fluoro-2-methoxyphenyl)-2-trifluoromethyl-pentyl]-ester | HCID 18350645 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-[2-Hydroxy-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-methyl-pentylamino]-phthalide | HCID 18350657 | — |
반응 단계
688 mg of 5-acetamidophthalide in 15 ml of dimethylformamide is mixed under argon at 0° C. with 108 mg of an 80% sodium hydride/oil suspension. After 10 minutes of stirring at this temperature, 556 mg of 4-toluenesulfonic acid-[2-hydroxy-4-(5-fluoro-2-methoxyphenyl)-2-trifluoromethyl-pentyl]-ester is added. After 16 hours of stirring at 60° C., it is added to 1 M hydrochloric acid, neutralized with potassium carbonate and extracted with ethyl acetate. After drying (Na2SO4), the crude product is chromatographed on silica gel. With hexane/ethyl acetate (60:40), the title compound is obtained in a crystalline state, flash point 148-149° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06323199B1 |
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| 출처 데이터셋 | uspto-grants-2001_11 |
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| ORD ID | ord-2f3204f144704d4e8ba7a9135a48a5be |
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| 출처 메모 | uspto-grants-2001_11 |
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