Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m-Chloroperbenzoic acid → tert-butyl 2-[2-(2-butyl-5-oxido-1H-imidazo[4,5-c]quinolin-1-yl)ethoxy]ethylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | tert-butyl 2-[2-(2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)ethoxy]ethylcarbamate | HCID 21898025 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | tert-butyl 2-[2-(2-butyl-5-oxido-1H-imidazo[4,5-c]quinolin-1-yl)ethoxy]ethylcarbamate | HCID 21898031 | 85.9% |
반응 단계
A solution of tert-butyl 2-[2-(2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)ethoxy]ethylcarbamate (4.12 g, 10.0 mmol) in 50 mL of CH2Cl2 was treated with 3-chloroperoxybenzoic acid (MCPBA, 77%, 2.5 g, 11.2 mmol). After stirring for 5 h, the reaction mixture was treated with saturated NaHCO3 solution and the layers were separated. The organic portion was washed with H2O and brine then dried over Na2SO4 and concentrated to give 3.68 g of tert-butyl 2-[2-(2-butyl-5-oxido-1H-imidazo[4,5-c]quinolin-1-yl)ethoxy]ethylcarbamate as a light brown foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06656938B2 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-998bdc43df004b70b3c578b1ff0ecdb5 |
| 출처 메모 | uspto-grants-2003_12 |