Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 5-(2,2,4-Trimethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | [5-(2,2,4-Trimethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-carbamic acid tert-butyl ester | HCID 66914640 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 5-(2,2,4-Trimethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine | HCID 66914602 | 75% |
반응 단계
A mixture of [5-(2,2,4-trimethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-carbamic acid tert-butyl ester (Step 110.2) (1.94 g, 5.8 mmol), a 4 N solution of HCl in dioxane (20 mL) and MeOH (5 mL) was stirred for 12 h at it and concentrated. The residue was purified by silica gel column chromatography (DCM/NH3aq, 99:1→DCM/MeOH/NH3aq, 95:4:1) to afford 1.02 g of the title compound as a white solid. Title compound: ESI-MS: 235.2 [M+H]+; TLC: Rf=0.11 (DCM/MeOH, 9:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536175B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-15150eafde074e36bfe09ca264bc2d6b |
| 출처 메모 | uspto-grants-2013_09 |