Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetyl chloride → 2,2,2-trifluoro-N-(4-{[5-(methylthio)pentyl]amino}quinolin-3-yl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetyl chloride | HCID 61106 | — |
| 반응물 | N4-[5-(methylthio)pentyl]quinoline-3,4-diamine | HCID 22320477 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2,2,2-trifluoro-N-(4-{[5-(methylthio)pentyl]amino}quinolin-3-yl)acetamide | HCID 22320519 | 153.8% |
반응 단계
A cool solution of trifluoroacetyl chloride (3.5 g, 26.5 mmol) in toluene was slowly added to a solution of N4-[5-(methylthio)pentyl]quinoline-3,4-diamine (6 g, 23.1 mmol) in a mixture of toluene and pyridine. A heavy yellow precipitate formed. The reaction mixture was stirred over the weekend and then concentrated under reduced pressure to provide 13.2 g of crude 2,2,2-trifluoro-N-(4-{[5-(methylthio)pentyl]amino}quinolin-3-yl)acetamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06667312B2 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-736730e5e5c7467bb84e812690593f2e |
| 출처 메모 | uspto-grants-2003_12 |