Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroform → 2-amino-N-(2-chlorophenyl)-5-hydroxybenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | 2-Chloroaniline | HCID 7240 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 5-Hydroxyanthranilic acid | HCID 164592 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 2-amino-N-(2-chlorophenyl)-5-hydroxybenzamide | HCID 22316564 | 12% |
반응 단계
Prepared according to Procedure A using 2-amino-5-hydroxybenzoic acid (5.0 g, 32.7 mmol) and SOCl2 (6.0 mL, 81.6 mmol) in benzene (150 mL), followed by 2-chloroaniline (6.9 mL, 65.4 mmol) and CHCl3 (150 mL). The product was purified by two chromatographies in MeOH/CH2Cl2 to provide 990 mg of a brown solid (12%). 1H NMR (MeOH-d4) δ: 7.92 (dd, J=1.6, 8.1 Hz, 1H); 7.48 (dd, J=1.5, 7.7 Hz, 1H); 7.34 (dt, J=1.5, 7.7 Hz, 1H); 7.20 (dt, J=1.7, 7.7 Hz, 1H); 7.16 (d, J=2.7 Hz, 1H); 6.83 (dd, J=2.7, 8.7 Hz, 1H); 6.76 (d, J=8.7 Hz, 1H); [6.24 (br s, 2H)). MS (ES): m/z 263.0 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06667300B2 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-ab30ca18b73141689e84ed1002d9df2b |
| 출처 메모 | uspto-grants-2003_12 |