Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methoxyphenol → alpha-Hydroxy-beta-(3-Methoxyphenoxy)-N-(1-Methylethyl)Benzenepropanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methoxyphenol | HCID 9007 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 18-Crown-6 | HCID 28557 | — |
| 반응물 | N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide | HCID 13041334 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | alpha-Hydroxy-beta-(3-Methoxyphenoxy)-N-(1-Methylethyl)Benzenepropanamide | HCID 13041339 | — |
반응 단계
This compound was prepared from N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide (10.3 g.), m-methoxyphenol (6.2 g.), sodium hydride (50% oil dispersion, 2.4 g.), 18-crown-6 (1.5 g.) and acetonitrile (500 ml.) as described in Example 12. The crude product (m.p. 118°-120°, yield 2.6 g.) was then recrystallized from ether with a small amount of tetrahydrofuran, giving 2.3 g. of the pure product, m.p. 132°-133°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04401832 |
| 출처 데이터셋 | uspto-grants-1983_08 |
| ORD ID | ord-a93e2cdd291a4405bdf8eab496f6903a |
| 출처 메모 | uspto-grants-1983_08 |