Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Naphthaleneethanol → 4-Benzamido-1-[2-(2-naphthyl)ethyl]piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Naphthaleneethanol | HCID 73877 | — |
| 반응물 | N-4-Piperidylbenzamide | HCID 118120 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 4-Benzamido-1-[2-(2-naphthyl)ethyl]piperidine | HCID 21430613 | — |
반응 단계
2-(2-Naphthyl)ethanol (3.44 g., 0.02 mole), 4-benzamidopiperidine (4.08 g., 0.02 mole) and Raney Nickel (W7 ca. 5 g.) were suspended in xylene (200 ml.) and the stirred mixture boiled under reflux for 16 hours. Liberated water was removed by means of a Dean and Stark apparatus. The mixture was filtered hot and evaporated to ca. 100 ml. The resulting yellow solution was stored until crystallisation was complete. The title compound was obtained as off-white needles (3.30 g.), m.p. 189°-191° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04029801 |
| 출처 데이터셋 | uspto-grants-1977_06 |
| ORD ID | ord-f0ae86a5d7d94fe7a08083e5cbbad43a |
| 출처 메모 | uspto-grants-1977_06 |