Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | N-tert-Butoxycarbonyl-L-tryptophan | HCID 83169 | — |
| 반응물 | L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- | HCID 90234 | — |
| 반응물 | BOC-D-alanine | HCID 637606 | — |
| 반응물 | Boc-D-Tyr(Bzl)-Oh | HCID 6992575 | — |
| 생성물 | Nalpha-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine methyl ester | HCID 54340573 | — |
반응 단계
Nα-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine resin is obtained according to the procedure of Example 1 by treating 20 g. of Nα-t-butoxycarbonyl-D-alanine resin, 0.0132 mol, with 7.4 g., 0.02 mol, of Nα-t-butoxycarbonyl-O-benzyl-D-tyrosine and 4.1 g., 0.02 mol, of dicyclohexylcarbodiimide, (2) 6.0 g., 0.02 mol, of Nα-t-butoxycarbonyl-O-benzyl-L-serine and 4.1 g. of dicyclohexylcarbodiimide, and (3) 6.1 g. of Nα-t-butoxycarbonyl-L-tryptophan and 4.1 g. of dicyclohexylcarbodiimide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04031069 |
| 출처 데이터셋 | uspto-grants-1977_06 |
| ORD ID | ord-a241e9b4db8e44bd8139d5072b78c7cf |
| 출처 메모 | uspto-grants-1977_06 |