Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyanoacetamide → alpha-Cyano-beta-(2-Nitro-4,5-Dimethoxyphenyl)Acrylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyanoacetamide | HCID 7898 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 6-Nitroveratraldehyde | HCID 88505 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | alpha-Cyano-beta-(2-Nitro-4,5-Dimethoxyphenyl)Acrylamide | HCID 4145653 | — |
반응 단계
Piperidine (2.1 g., 0.0237 mole) and 2-cyanoacetamide (22.0 g., 0.263 mole) are added to a slurry of 6-nitroveratraldehyde (50.0 g., 0.237 mole) in methanol (500 ml.). The mixture is heated to reflux for 2 hours, and then cooled in an ice bath and filtered. The bright yellow filter cake is washed with cold isopropanol (300 ml.) and then air dried. Yield = 60.1 g. (93%); m.p. 265°-266° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04044134 |
| 출처 데이터셋 | uspto-grants-1977_08 |
| ORD ID | ord-25c95626a215461da2793469a09d051f |
| 출처 메모 | uspto-grants-1977_08 |