참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| 반응물 | 4-(1-Triisopropylsilanyl-1H-pyrrol-3-ylmethyl)-morpholine | HCID 66636760 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(1H-Pyrrol-3-ylmethyl)-morpholine | HCID 57587018 | — |
반응 단계
To a solution of the compound obtained in Step A (75 mmoles) in THF (100 ml) there is added, dropwise, at 0° C., Bu4NF 1.0M in THF (75.0 mmoles). After stirring at 0° C. for one hour, the solution is poured onto ice and is then extracted with DCM. The organic phases are combined and then washed with saturated aqueous NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness to yield the title product, which is used directly in the next Step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08541412B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-7cecaa6b366145c09e288eccc4d1f28e |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
