참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia acetate | HCID 12432 | — |
| 반응물 | Triethyl orthoacetate | HCID 66221 | — |
| 반응물 | 2-Amino-4,5-dimethyl-thiophene-3-carbonitrile | HCID 290236 | — |
| 생성물 | 2,5,6-Trimethylthieno[2,3-d]pyrimidin-4-amine | HCID 25224341 | 60% |
반응 단계
A mixture of 2-amino-4,5-dimethylthiophene-3-carbonitrile (200 mg, 1.32 mmol), ammonia acetate (204 mg, 2.64 mmol), and triethyl orthoacetate (2.0 mL) was stirred in a sealed tube at 120° C. overnight. After the reaction mixture was cooling down to room temperature, the precipitate was collected by filtration, rinsed with EtOAc and dried in the air to give title compound (52 mg, 60%) as a yellow solid. 1H NMR (400 MHz, CDCl3) δ2.41 (s, 3H), 2.45 (s, 3H), 2.56 (s, 3H), 5.28 (bs, 2H). MS 194 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08541421B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-351ac407a6b3414eafc82a489c82274a |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
