참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Isopropyl iodide | HCID 6362 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Amino-4,5-dimethoxybenzonitrile | HCID 735967 | — |
| 촉매 | Copper | HCID 23978 | — |
| 생성물 | 2-Isopropylamino-4,5-dimethoxy-benzonitrile | HCID 60112825 | — |
반응 단계
A suspension of 4.52 g (25.4 mmol) 2-amino-4,5-dimethoxy-benzonitrile, 4.38 g (31.7 mmol) potassium carbonate and 100 mg copper powder in 15 ml 2-iodo-propane is stirred at 90° C. for 5 days. Extractive work-up with ethyl acetate/water and concentration i.V. affords a dark oil, which is purified by flash chromatography (ethyl acetate/hexane). yield: 4.15 g (74%) yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08476286B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_07 |
|---|
| ORD ID | ord-55a58d2306c7437e944ba3e9a8eac496 |
|---|
| 출처 메모 | uspto-grants-2013_07 |
|---|
