Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluorophenyl isocyanate → (1R,3S)-1-(4-bromophenyl)-N-(4-fluorophenyl)-3-methyl-3,4-dihydroisoquinoline-2(1H)-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluorophenyl isocyanate | HCID 70955 | — |
| 반응물 | (1R,3S)-1-(4-bromophenyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline | HCID 59536341 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (1R,3S)-1-(4-bromophenyl)-N-(4-fluorophenyl)-3-methyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | HCID 59536370 | — |
반응 단계
To a solution of (1R,3S)-1-(4-bromophenyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline (48.5 mg, 160 μmol) in CH2Cl2 (1.0 mL) at RT was added 1-fluoro-4-isocyanatobenzene (28.9 μL, 249 μmol). The reaction was stirred 4 h and directly purified by reverse phase HPLC to give (1R,3S)-1-(4-bromophenyl)-N-(4-fluorophenyl)-3-methyl-3,4-dihydroisoquinoline-2(1H)-carboxamide as a white solid. MS (ESI pos. ion) m/z: 439, 441 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08476297B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-77bea610ce9a4a198f7f0cf32d383a54 |
| 출처 메모 | uspto-grants-2013_07 |