Ethanol → Sri 62320

참여 물질

반응 단계

E-(7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide (3.0 g), ethyl alcohol (30.0 mL), and a solution of sodium hydroxide (0.4 g) in water (3.0 mL) were added to a reactor. The reaction mixture was stirred for 16 hours while maintaining the temperature of 20˜25° C. and then concentrated under reduced pressure. The resulting residue was dissolved in chloroform (10.0 mL) and then diethyl ether (100.0 mL) was added thereto. The reaction mixture was stirred for over 5 hours and then filtered under reduced pressure. The resulting white solid was dried under vacuum to obtain (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy hept-6-enoic acid sodium salt (2.4 g, yield 85%).

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