참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Azanium;hydrate | HCID 22024077 | — |
| 반응물 | ethyl 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate | HCID 44232943 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | HCID 44235652 | 54% |
반응 단계
1.0 g (2.6 mmol) of ethyl 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate were dissolved in a mixture of 100 mL of methanol and 100 mL of ammonium hydrate 33%. The solution was stirred in a close bottle at 60° C. for 4 hours. The resulting precipitate was collected giving 0.5 g (54% yield) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08541429B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-6b4bb62a093749f2af071cd03ebe2fc4 |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
