Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromine → 2-Bromo-1-(3-chloro-4-methoxyphenyl)ethan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 3'-Chloro-4'-methoxyacetophenone | HCID 520857 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Bromo-1-(3-chloro-4-methoxyphenyl)ethan-1-one | HCID 10611613 | 70% |
반응 단계
To a solution of 1-(3-chloro-4-methoxyphenyl)ethanone (1.0 g, 5.42 mmol) in MeOH (29.5 mL) was added a solution of bromine (0.33 mL, 6.50 mmol) in MeOH (10 mL) at RT. The reaction mixture was then stirred for 2 h, quenched with ice and extracted with DCM (2×20 mL). The combined organic layers were washed with water, dried over Na2SO4, and concentrated in vacuo to afford 2-bromo-1-(3-chloro-4-methoxyphenyl)ethanone (1.0 g, 70%) as solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08481534B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-33888efdb6984ef49eddd2c1d0c0aa5e |
| 출처 메모 | uspto-grants-2013_07 |