Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N'-(2-bromophenyl)sulfonyl-N,N-dimethylmethanimidamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 반응물 | Sodium Bisulfate | HCID 516919 | — |
| 반응물 | 2-Bromobenzenesulfonamide | HCID 2801263 | — |
| 생성물 | N'-(2-bromophenyl)sulfonyl-N,N-dimethylmethanimidamide | HCID 11779014 | 96.6% |
반응 단계
1,1-Dimethoxy-N,N-dimethylmethanamine (14.6 mL, 104 mmol) was added to a solution of 2-bromobenzene-1-sulfonamide (20.4 g, 86.4 mmol) in DMF (56 mL, 720 mmol) and the resulting solution was stirred at room temperature for 90 minutes. A solution of sodium hydrogen sulfate (1.7 g, 14 mmol) in water (170 mL, 9.4 mol) was cooled at 0° C. and then added to the reaction mixture. The precipitate was filtered, washed with water, and dried to yield 2-bromo-N-[1-dimethylaminometh-(E)-ylidene]benzenesulfonamide (24.3 g) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08481549B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-a79242ee748e4b0b80a9bb94c7bad53b |
| 출처 메모 | uspto-grants-2013_07 |