Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,4,6-Trimethyl-2-vinyl-1,3,2-dioxaborinane → (3R)-3-fluoro-1-(4-((E)-2-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)vinyl)benzyl)pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,4,6-Trimethyl-2-vinyl-1,3,2-dioxaborinane | HCID 107310 | — |
| 반응물 | (R)-1-(4-bromobenzyl)-3-fluoropyrrolidine | HCID 66730391 | — |
| 생성물 | (3R)-3-fluoro-1-(4-((E)-2-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)vinyl)benzyl)pyrrolidine | HCID 66734517 | — |
반응 단계
The title compound was synthesized according to the method of Example A51A, except substituting (R)-1-(4-bromobenzyl)-3-fluoropyrrolidine (1.07 g, 4.15 mmol) and 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane (0.77 mL, 4.57 mmol) which gave 1.40 g, 91% of a pale orange solid; MS ESI [M+H]+ 332.3, calcd for [C19H27BFNO2+H]+ 332.22.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08481533B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-d79389c59a8b4a52b5ff99823fb34656 |
| 출처 메모 | uspto-grants-2013_07 |