Potassium Carbonate → 4-[6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-ylamino]-piperidine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/ko/reaction/448564

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	Dimethylacetamide	HCID 31374	—
반응물	4-Amino-1-Boc-piperidine	HCID 1268291	—
반응물	1-(6-Chloropyrimidin-4-yl)-5-(methylsulfonyl)indoline	HCID 59566526	—
용매	Sodium chloride; water	HCID 57417360	—
생성물	4-[6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-ylamino]-piperidine-1-carboxylic acid tert-butyl ester	HCID 58074125	—

반응 조건

온도	80 °C

반응 단계

A mixture of 6a (0.4 g, 1.29 mmol), 4-amino-piperidine-1-carboxylic acid tert-butyl ester (0.4 g, 1.5 eq), DMA (5 mL) and potassium carbonate (0.4 g, 2.2 eq) was heated at 80° C. for 42 h. After allowing the reaction mixture to cool down to room temperature, 100 mL of brine was added and the mixture was extracted with ethyl acetate twice (100 mL and 30 mL). The combined extracts were washed with brine (2×50 mL), dried over magnesium sulfate and filtered. The solvent was removed under vacuum to give a solution of 6b in DMA.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08481731B2
출처 데이터셋	uspto-grants-2013_07
ORD ID	ord-4a1b421ad8224d65bd9a3b41614f8ef6
출처 메모	uspto-grants-2013_07