참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2,4-Dichloro-1,3,5-triazine | HCID 17810 | — |
| 반응물 | 5-(Methanesulfonyl)-2,3-dihydro-1H-indole | HCID 2736136 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 촉매 | Binap, (A+-)- | HCID 634876 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-(4-Chloro-[1,3,5]-triazin-2-yl)-5-methanesulfonyl-2,3-dihydro-1H-indole | HCID 86650175 | 83.7% |
반응 단계
5-Methanesulfonyl-2,3-dihydro-1H-indole (79 mg, 0.4 mmol) was dissolved in dioxane (2 mL). 2,4-Dichloro-[1,3,5]-triazine (60 mg, 1 eq), palladium acetate (11 mg, 5% molar), (+/−)binap (15 mg, 8% molar) and cesium carbonate (131 mg, 1 eq) were added and the reaction mixture was heated at 100° C. for 4 h. The mixture was cooled to room temperature and water was added. The mixture was filtered through celite and washed three times with dioxane. The collected filtrate was evaporated to dryness to give 11a (104 mg) which was used for the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08481731B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_07 |
|---|
| ORD ID | ord-c6be3730c18143329c854589768305da |
|---|
| 출처 메모 | uspto-grants-2013_07 |
|---|
