Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → [2-(3-Bromophenoxy)ethyl]dimethylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 3-Bromophenol | HCID 11563 | — |
| 반응물 | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | [2-(3-Bromophenoxy)ethyl]dimethylamine | HCID 413371 | — |
반응 단계
3-Bromophenol (0.870 g, 5.00 mmol), (2-chloro-ethyl)-dimethylamine hydrochloride (0.792 g, 5.50 mmol) and Cs2CO3 (8 g, 25 mmol) were combined in DMF (20 mL) and the mixture was heated at reflux over night. H2O (20 mL) was added and the mixture was extracted with EtOAc, then washed with 2N NaOH and brine. The organic layers were combined, dried over Na2SO and concentrated to a brown oil which was then purified by flash chromatography (eluent: 20% EtOAc in hexanes).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08481733B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-7b6c563c346040629f1a39ef6f906e44 |
| 출처 메모 | uspto-grants-2013_07 |