Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methoxy-5-nitropyrimidine → 2-Methoxypyrimidin-5-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methoxy-5-nitropyrimidine | HCID 352900 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Methoxypyrimidin-5-amine | HCID 352904 | 100% |
반응 단계
To 0.342 g (2.20 mmol) of the above nitro compound in MeOH (20 mL) was added 0.30 g of 10% Pd/C and the mixture was stirred under hydrogen (25 in/Hg) for 18 hrs. The reaction mixture was filtered through celite, and concentrated, to give 0.274 g (100% yield) of 5-amino-2-methoxypyrimidine as a colorless oil: 1H NMR (DMSO-d6) δ 8.05 (s, 2H), 3.94 (s, 3H); LCMS (APCI+) m/z: 126 (MH+, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08486939B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-baaf8f4908814131a2da245bbc3ce777 |
| 출처 메모 | uspto-grants-2013_07 |