Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetyl chloride → 2-Chloromethyl-3-(2-chlorophenyl)-5-methyl-3H-quinazolin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | 2-Amino-N-(2-chlorophenyl)-6-methylbenzamide | HCID 16785685 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-Chloromethyl-3-(2-chlorophenyl)-5-methyl-3H-quinazolin-4-one | HCID 22316547 | 24% |
반응 단계
Prepared according to Procedure B with 1g (2.18 g, 8.36 mmol) and chloroacetyl chloride (2.0 mL, 25.1 mmol) in acetic acid (40 mL). Purified by two chromatographies in CH2Cl2 and EtOAc/hexanes, followed by recrystallization from isopropanol to afford 638 mg of an off-white crystalline solid (24%). 1H NMR (DMSO-d6) δ: 7.73-7.80 (m, 3H); 7.58-7.64 (m, 3H); 7.41 (d, J=7.4 Hz, 1H); 4.40 (d, J=12 Hz, 1H), 4.26 (d, J=12 Hz, 1H); 2.74 (s, 3H). MS (ES): m/z 319.0 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08492389B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-43129f9f3d3642d98b8dd49ff7020b1e |
| 출처 메모 | uspto-grants-2013_07 |