Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → [1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-3-yl]acetic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromomethyl-1,4-benzodioxane | HCID 98333 | — |
| 반응물 | Ethyl 2-(piperidin-3-yl)acetate | HCID 2760464 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | [1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-3-yl]acetic acid ethyl ester | HCID 25175968 | — |
반응 단계
To a mixture of 2-bromomethyl-2,3-dihydrobenzo[1,4]dioxine (1.34 g, 5.84 mmol), piperidin-3-yl-acetic acid ethyl ester (1.0 g, 5.84 mmol) in acetonitrile (25 ml) was added K2CO3 (0.81 g, 5.84 mmol) and KI (0.97 g, 5.84 mmol). The reaction mixture was irradiated under microwaves at 82° C. for 8 h. Water (100 ml) was then added. The reaction mixture was extracted with DCM (3×50 ml). The combined organic phases were dried (Na2SO4), filtered and the filtrate was evaporated to give the title compound, which was purified by column chromatography (DCM/MeOH, 95:5).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08492549B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-ec27fb45c4784a3bb44e10e77920f75d |
| 출처 메모 | uspto-grants-2013_07 |