Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Benzylbenzoic acid → N-Benzyl-2-(4-benzylbenzamido)-4-((methylamino)methyl)thiazole-5-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Benzylbenzoic acid | HCID 136429 | — |
| 반응물 | 2-amino-N-benzyl-4-((methylamino)methyl)thiazole-5-carboxamide | HCID 86642526 | — |
| 생성물 | N-Benzyl-2-(4-benzylbenzamido)-4-((methylamino)methyl)thiazole-5-carboxamide | HCID 59369653 | — |
반응 단계
Following the procedure as described in Example 22, making variation only as required to use 2-amino-N-benzyl-4-((methylamino)methyl)thiazole-5-carboxamide in place of 2-amino-N-benzyl-4-((diethylamino)methyl)thiazole-5-carboxamide to react with 4-benzylbenzoic acid, the title compound was obtained; 1H NMR (CD3OD, 400 MHz) δ 7.93 (d, J=8.6 Hz, 2H), 7.35-7.15 (m, 12H), 4.49 (s, 2H), 4.06 (s, 2H), 4.02 (s, 2H), 3.09 (s, 2H), 2.37 (s, 3H); MS (ES+) m/z 471 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541457B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-4549abaaf6b6470a897475084baa2be9 |
| 출처 메모 | uspto-grants-2013_09 |