Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methyluracil → 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-3-methylpyrimidine-2,4(1H,3H)-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methyluracil | HCID 79066 | — |
| 반응물 | 3-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride | HCID 67028719 | — |
| 생성물 | 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-3-methylpyrimidine-2,4(1H,3H)-dione | HCID 67028711 | — |
반응 단계
The title compound was prepared according to Method B and the experimentals described for compound 92 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and 3-methylpyrimidine-2,4(1H,3H)-dione. M/e+ 367 for C19H16ClN4O2 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.22 (d, J=5.8 Hz, 1H), 7.66 (d, J=8.4 Hz, 2H), 7.45 (d, J=8.4 Hz, 2H), 7.30 (m, 1H), 6.91 (t, J=6.6 Hz, 1H), 6.63 (d, J=8.0 Hz, 1H), 5.56 (d, J=8.0 Hz, 1H), 5.45 (s, 2H), 5.26 (d, J=0.7 Hz, 1H), 3.34 (s, 3H) ppm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08497278B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-7c55faf6bc304f948282c47f2073fa58 |
| 출처 메모 | uspto-grants-2013_07 |