Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-((4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)methyl)oxirane → 1-[N-[2-(3-carbamoyl-4-hydroxy-phenoxy)-ethyl]-benzylamino]-3-[4-[2-(cyclopropylmethoxy)ethyl]-phenoxy]-2-propanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-((4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)methyl)oxirane | HCID 11791542 | — |
| 반응물 | 5-(2-Benzylaminopropoxy)salicylamide | HCID 13754334 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 1-[N-[2-(3-carbamoyl-4-hydroxy-phenoxy)-ethyl]-benzylamino]-3-[4-[2-(cyclopropylmethoxy)ethyl]-phenoxy]-2-propanol | HCID 20151321 | — |
반응 단계
A solution of 14.3 g of 1-[2-(cyclopropyl-methoxy)ethyl]-4-(2,3-epoxypropoxy)-benzene (German Offenlegungsschrift No. 2,649,605) and 16.3 g of 5-[2-(benzylamino)propoxy]-salicylamide in 200 ml of isopropanol is refluxed for 18 hours. The reaction mixture is concentrated by evaporation to leave crude 1-[N-[2-(3-carbamoyl-4-hydroxy-phenoxy)-ethyl]-benzylamino]-3-[4-[2-(cyclopropylmethoxy)ethyl]-phenoxy]-2-propanol in the form of brown oil, which can be further processed without additional purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04727067 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-b95195d2cd784a148d1234c8bc6ee701 |
| 출처 메모 | uspto-grants-1988_02 |