Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 456439생성일: 2026년 10월 24일
Triphenylphosphine → 4-[2-(2-Morpholin-4-yl-ethoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/ko/reaction/456439
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 2-Morpholinoethanol | HCID 61163 | — |
| 반응물 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 반응물 | Tert-butyl 4-(2-hydroxyphenyl)piperazine-1-carboxylate | HCID 11543684 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-[2-(2-Morpholin-4-yl-ethoxy)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 18436764 | 64% |
반응 단계
Diisopropyl azodicarboxylate (0.48 mL, 2.4 mmol) was added dropwise to a stirred solution of 4-(2-hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.56 g, 2 mmol), 2-morpholin-4-yl-ethanol (0.24 mL, 2 mmol) and triphenylphosphine (0.63 g, 2.4 mmol) in THF (20 mL) cooled to 0° C. The resulting solution was warmed to r.t. and stirred for about 16 hours. The solvent was removed in vacuo and the residue purified by silica gel chromatography (ethyl acetate) to afford the final compound (0.50 g, 64%) as a clear oil
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07186715B2 |
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| 출처 데이터셋 | uspto-grants-2007_03 |
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| ORD ID | ord-a1e654ad91ad4cd192c716c8c40a3aaa |
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| 출처 메모 | uspto-grants-2007_03 |
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