Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 2-Ethenylquinoxaline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Dimethyl Sulfate | HCID 6497 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 5-Cyanomethylbenz-2,1,3-thiadiazole | HCID 69522445 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Ethenylquinoxaline | HCID 21803421 | 66% |
반응 단계
Dimethyl sulfate (1.07 ml, 11.3 mmol) was added dropwise, while maintaining the mixture temperature below 40° C., to a solution of amine (a) (2.6 g 11.3 mmol) in ethanol (3 ml). The thick mixture was diluted with water (15 ml) then triethylamine (1.13 ml) was added and the mixture heated for 2 hours on a water bath. After cooling the mixture was extracted with diethyl ether. The organic phase was dried over magnesium sulfate, concentrated to dryness and the residue was chromatographed on silica eluting with heptane-ethyl acetate (3-1) to give the product (1.16 g, 66%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07186730B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-3a2816ff52c14b7685cc57f5e516a080 |
| 출처 메모 | uspto-grants-2007_03 |