참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Cinnamylpiperazine | HCID 86803 | — |
| 반응물 | 4-(3-Piperidin-1-ylpropoxy)benzaldehyde | HCID 2766324 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | Ammonia dichloromethane | HCID 22731429 | 1% |
| 생성물 | 1-(3-Phenyl-allyl)-4-[4-(3-piperidin-1-yl-propoxy)-benzyl]-piperazine | HCID 68700327 | — |
반응 단계
A solution of the product of Example 9 (215 mg), 1-(3-phenyl-allyl)-piperazine (176 mg), and acetic acid (0.06 mL) in DCM (3 mL) was treated with sodium triacetoxyborohydride (290 mg). After 16 h, the resulting mixture was treated with 10% sodium hydroxide (5 mL) and extracted with DCM (3×10 mL). The combined organic phases were dried (sodium sulfate) and evaporated. Chromatography of the residue (1–5% 2 M methanolic ammonia/DCM) gave the title compound as a colorless oil (303 mg). 1H NMR (400 MHz, CDCl3): 7.36 (m, 2H), 7.30 (m, 2H), 7.24–7.18 (m, 3H), 6.83 (d, J=8.6 Hz, 2H), 6.51 (d, J=15.9 Hz, 1H), 6.31–6.23 (m, 1H), 3.98 (t, J=6.3 Hz, 2H), 3.45 (s, 2H), 3.15 (m, 2H), 2.60–2.32 (m, 12H), 1.67 (br, 1H), 1.62–1.56 (m, 4H), 1.47–1.40 (m, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07186732B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_03 |
|---|
| ORD ID | ord-5561b61465704a789ecf559db8adeca0 |
|---|
| 출처 메모 | uspto-grants-2007_03 |
|---|
