Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-(Hydroxymethyl)-1-[(4-methoxyphenyl)methyl]pyrrolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl 1-(4-methoxybenzyl)-5-oxopyrrolidine-3-carboxylate | HCID 4093874 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(Hydroxymethyl)-1-[(4-methoxyphenyl)methyl]pyrrolidin-2-one | HCID 13422559 | — |
반응 단계
NaBH4 (15 g, 0.081 mol) was added in portions to ester 79 in ethanol (600 mL) at room temperature. After 4.5 hours water (˜200 mL) was carefully added to the reaction and the solution stirred at room temperature overnight. The resultant solid was removed by filtration and the filtrate concentrated to give alcohol 80 as an oil. 15.33 g, 81%. MS, m/z (relative intensity): 235 [M+H, 100%].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07189747B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-d710770dbbb94e9eb465409b61058f5b |
| 출처 메모 | uspto-grants-2007_03 |