Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Octoxybenzoyl hydrazine | HCID 4281533 | — |
| 반응물 | 2,5-Dibromobenzoyl chloride | HCID 13450524 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide | HCID 21982102 | 126.5% |
반응 단계
Under a blanket of nitrogen, 2,5-dibromobenzoyl chloride (57.43 g, 0.11925 mol) was added to a solution of 4-octyloxybenzoic acid hydrazide (50.88 g, 0.1925 mol) and triethylamine (27 mL, 19.48 g, 0.1925 mol) in 800 mL of methylene chloride. The reaction mixture was stirred for 5 hours at room temperature. The precipitated solid was filtered off and re-crystallized from hot DMF/water gave 79.38 g (78% yield) 2,5-dibromo-N′-[4-(octyloxy)benzoyl]benzohydrazide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07192657B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-3c90c261d377472f80df95c24aa86fa6 |
| 출처 메모 | uspto-grants-2007_03 |