Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → HCID 178425128, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Aminobenzimidazole | HCID 13623 | — |
| 반응물 | Benzene, 1-(bromomethyl)-2-fluoro-3-methyl- | HCID 519062 | — |
| 생성물 | HCID 178425128 | HCID 178425128 | — |
반응 단계
The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 2-fluoro-3-methylbenzylbromide (447 mg; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.072 g (19.1%); MS m/z: 378.1 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 2.24 (d, 6H, 4JH,F=1.5 Hz); 4.71 (s, 4H); 6.67-6.69 (m, 2H); 6.98 (t, 2H, 3J=7.5 Hz); 7.03-7.06 (m, 2H); 7.13-7.15 (m, 2H), 7.33-7.35 (m, 1H); 7.92 (s, 1H); 11.95 (br s, 1H); HPLC (METHOD [A]): rt 17.77 min (83.5%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541596B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-0811b89b739542fcadd2a0bd3390a44d |
| 출처 메모 | uspto-grants-2013_09 |