Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 5-Amino-1-methyl-4-phenoxycarbonylaminopyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Phenyl chloroformate | HCID 15891 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 1H-Pyrazole, 4,5-diamine-1-methyl-, sulfate (1:1) | HCID 21904571 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Amino-1-methyl-4-phenoxycarbonylaminopyrazole | HCID 21904460 | 88.8% |
반응 단계
A solution of 4,5-diamino-1-methylpyrazole sulfate (158 g) in water (1.1 L) was neutralized to pH 6.9 with 4N aqueous sodium hydroxide solution, and dioxane (474 ml) was added to this solution. To the resulting mixture was added dropwise phenyl chloroformate (124 g) maintaining pH of the mixture at 6.9 with 4N aqueous sodium hydroxide solution at a temperature below 10° C. The reaction mixture was stirred for 1 hour. The precipitated solid was collected by filtration and dried to give 5-amino-1-methyl-4-phenoxycarbonylaminopyrazole (155 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07192943B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-b8cf7690c27a47429de8e16d9808c19f |
| 출처 메모 | uspto-grants-2007_03 |