Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium cyanoborohydride → (6,4'-Dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-8-yl-ethyl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | 1-(Quinolin-8-yl)ethan-1-amine | HCID 12208793 | — |
| 반응물 | 6,4'-Dimethoxybiphenyl-3-carbaldehyde | HCID 22391191 | — |
| 반응물 | (6,4'-Dimethoxybiphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine | HCID 22391337 | — |
| 생성물 | (6,4'-Dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-8-yl-ethyl)-amine | HCID 22391354 | 72% |
반응 단계
The title compound was prepared by the same procedure for (6,4′-dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine from 1-quinolin-8-yl-ethylamine (510 mg, 3.0 mmol), 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (242 mg, 1.0 mmol) and sodium cyanoborohydride (1.0 g, 16 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 72% yield (287 mg, 0.72 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07196102B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-3775a5953e614470b6b29c98e339b3bb |
| 출처 메모 | uspto-grants-2007_03 |