Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 3-Amino-1-(3-bromo-4-chlorobenzyl)-pyrazol-5-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | beta-Aminobeta-ethoxyacrylic acid ethyl ester | HCID 278451 | — |
| 반응물 | 3-Bromo-4-chlorobenzylhydrazine | HCID 23334355 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-Amino-1-(3-bromo-4-chlorobenzyl)-pyrazol-5-one | HCID 20367315 | — |
반응 단계
49 g of β-amino-β-ethoxyacrylic acid ethyl ester and 2 g of p-toluenesulphonic acid were dissolved in 225 ml of ethanol and 72 g of 3 -bromo-4-chlorobenzylhydrazine were added under nitrogen. After standing overnight, the compound identified above had settled out as a precipitate and was filtered off and recrystallised twice from ethanol. Melting point: 171°-172° C, 40 g (43%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04061653 |
| 출처 데이터셋 | uspto-grants-1977_12 |
| ORD ID | ord-dc2f9e3c43324419b09926dd65c45197 |
| 출처 메모 | uspto-grants-1977_12 |