Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methylbenzenesulfonic acid → 3-Amino-1-(3-chloro-4-bromobenzyl)-pyrazol-5-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methylbenzenesulfonic acid | HCID 6925 | — |
| 반응물 | beta-Aminobeta-ethoxyacrylic acid ethyl ester | HCID 278451 | — |
| 반응물 | [(4-Bromo-3-chlorophenyl)methyl]hydrazine | HCID 20495799 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-Amino-1-(3-chloro-4-bromobenzyl)-pyrazol-5-one | HCID 20367220 | — |
반응 단계
48.8 g of 4-bromo-3-chlorobenzylhydrazine are added dropwise under nitrogen to a solution of 33.2 g of β-amino-β-ethoxyacrylic acid ethyl ester and 1.5 g of toluenesulphonic acid in 150 ml of ethanol. After stirring for a further two hours, the mixture was left to stand and the compound identified above began to crystallise out after four hours. It was filtered off and twice recrystallised from ethanol. Melting point: 145°-146°, 23 g (37%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04061653 |
| 출처 데이터셋 | uspto-grants-1977_12 |
| ORD ID | ord-b1355b9f8c884251b2a602436be410aa |
| 출처 메모 | uspto-grants-1977_12 |