Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → N-Methyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Methyl Isocyanate | HCID 12228 | — |
| 반응물 | N-(3-{3-[(Piperidin-1-yl)methyl]phenoxy}propyl)hydrazinecarbothioamide | HCID 13402923 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-Methyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide | HCID 13657336 | — |
반응 단계
1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.40 g (6 mmol) of methylisocyanate are added and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete the precipitation, and the precipitate is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04727081 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-fc8d952f1485405099b4c829a6ef36c1 |
| 출처 메모 | uspto-grants-1988_02 |