2'-Chloro-4'-nitrovaleranilide → N-(4-amino-2-chlorophenyl)pentanamide

참여 물질

반응 단계

2'-Chloro-4'-nitrovaleranilide (13.0 g.) is dissolved in warm glacial acetic acid (100 ml.) and iron powder (14 g.) is added portionwise to maintain gentle boiling. The resulting reaction mixture is refluxed for 1/2 hour and filtered. The filtrate is evaporated under reduced pressure and the residue is triturated with water. The solid that forms is collected (11.5 g.) and recrystallized from cyclohexane to yield 7,5 g., m.p. 96.5°-99° C.

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