Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium borohydride → 5-Benzyloxy-3-(2-hydroxyethyl)indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | Methyl 2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoacetate | HCID 21906905 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 5-Benzyloxy-3-(2-hydroxyethyl)indole | HCID 744849 | — |
반응 단계
A suspension of methyl 5-benzyloxyindol-3-ylglyoxylate (10 g.) and sodium borohydride (3.7 g.) in isopropanol (100 ml.) was stirred and refluxed for 5 hours. The cooled mixture was diluted with water and extracted with dichloromethane. Evaporation of the extract gave a pale yellow oil which crystallised from a mixture of toluene and petroleum ether to give 5-benzyloxy-3-(2-hydroxyethyl)indole as a white crystalline powder m.p. 97°-98°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04062869 |
| 출처 데이터셋 | uspto-grants-1977_12 |
| ORD ID | ord-23ec6525c4244b4f9f7f173e7a825fb9 |
| 출처 메모 | uspto-grants-1977_12 |